Volume 4, Issue 1, March 2019, Page: 14-18
A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †
Rathod Aravind Kumar, Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad, India; SemiochemicalDivision, CSIR- Indian Institute of Chemical Technology, Hyderabad, India
Nayaki Salvanna, Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad, India; Osmania University Post Graduate College, Medak, India
Biswanath Das, Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad, India
Jajula Kashanna, Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad, India; Department of Chemistry, Rajiv Gandhi University of Knowledge Technologie, Basar, India
Received: Feb. 23, 2019;       Accepted: Apr. 23, 2019;       Published: Jun. 17, 2019
DOI: 10.11648/j.wjac.20190401.13      View  599      Downloads  103
The formation of amides from carboxylic acids and amines has been catalyzed efficiently with sodium hydrogen sulfate adsorbed on silica gel (NaHSO4.SiO2) at room temperature to give the products in high yields. The conversion carried out under reflux requires less reaction times and forms the products in higher yields. The reaction is highly selective as it has been found that either or both of the substrates should be aliphatic but it is failure when the acid as well as the amine is aromatic. The method has been utilized for the preparation of a natural phenethyl amide derivative and its analogues.
Heterogeneous Catalysis, Carboxylic Acids, Amines, Amides, Nucleophilic Substitution
To cite this article
Rathod Aravind Kumar, Nayaki Salvanna, Biswanath Das, Jajula Kashanna, A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †, World Journal of Applied Chemistry. Vol. 4, No. 1, 2019, pp. 14-18. doi: 10.11648/j.wjac.20190401.13
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